Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If you study how to get healthcare systems to actually use or stop using proven practices, NIH will fund your research at scale.
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What this is
This R01 mechanism supports dissemination and implementation (D&I) science across NIH institutes and centers. Applicants propose studies that tackle real-world barriers to adopting proven health interventions, practices, programs, or policies—from initial adoption through sustainability and scale-up. The program also welcomes research on de-implementation (stopping harmful or low-value practices) and methodological advances in D&I measurement and theory. Clinical trials are optional. Awards are competitive and open to universities, nonprofits, small businesses, and government entities.
Who can apply
Eligible applicants include nonprofits with 501(c)(3) status, universities (public and private), small businesses, state and local governments, Native American tribal organizations, and for-profit organizations. Solo researchers must be affiliated with an eligible institution. No geographic restrictions.
Eligible applicant types
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public and State controlled institutions of higher education
- Small businesses
- State governments
- Public housing authorities/Indian housing authorities
- County governments
- Private institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- For profit organizations other than small businesses
- Native American tribal governments (Federally recognized)
- Special district governments
- Independent school districts
- City or township governments
Full description — from the agency
The purpose of this Notice of Funding Opportunity (NOFO) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (hereafter referred to as evidence-based interventions). Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. Applications that focus on re-implementation of evidence-based health services that may be disrupted amidst disasters (e.g., pandemics) remain relevant. All applications must be within the scope of the mission of one of the Institutes/Centers listed above.
Topics: dissemination and implementation research · evidence-based interventions · health services adoption · implementation science · healthcare scale-up · de-implementation
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.