Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If you've developed a health intervention or practice that works but struggles to reach real patients, this funds the science of scaling it.
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What this is
This R21 mechanism funds dissemination and implementation research—studying how to get proven health interventions actually used in practice. It covers identifying barriers to adoption, testing strategies for scale-up and sustainability, understanding de-implementation of ineffective practices, and advancing D&I methods and measurement. The funding spans 18 NIH institutes and centers, making it broad in scope but requiring research firmly grounded in health outcomes and evidence-based practice.
Who can apply
Extremely broad: universities, nonprofits (501(c)(3) and non-501(c)(3)), small businesses, for-profits, government agencies, tribal organizations, and independent school districts all qualify. No geographic restriction; projects must align with one of 18 NIH institutes/centers and focus on dissemination/implementation research in health.
Eligible applicant types
- Special district governments
- Private institutions of higher education
- Public housing authorities/Indian housing authorities
- Public and State controlled institutions of higher education
- For profit organizations other than small businesses
- State governments
- City or township governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal organizations (other than Federally recognized tribal governments)
- County governments
- Small businesses
Full description — from the agency
The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged.All applications must be within the scope of the mission of one of the Institutes/Centers listed above.
Topics: dissemination research · implementation science · evidence-based practice adoption · health intervention scale-up · de-implementation · clinical practice barriers
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.