National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)
Last verified by NonDilute: 2026-04-29. Official notice and agency instructions control.
If you have a cancer treatment or diagnostic innovation ready for human testing, this NIH grant funds the clinical trial infrastructure to take it from bench to early-phase patient studies.
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What this is
This NIH R01 grant supports researchers developing and testing new cancer treatment and diagnostic approaches through early-phase human clinical trials. Awards up to $499,999 are available for trials focused on targeted cancer interventions that align with specific NCI research priorities (Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program, or HIV and AIDS Malignancies Research Programs). The funding is open to a wide range of applicants including small businesses, nonprofits, universities, and for-profit organizations. This is a long-window opportunity with applications accepted through January 2027.
Who can apply
Eligible applicants include small businesses, nonprofits (with or without 501(c)(3) status), universities, for-profit organizations, government entities, and tribal organizations. The requirement is that your proposed project must implement at least one early-phase clinical trial (Phase 0, I, or II) focused on cancer-targeted diagnostics or therapeutics aligned with NCI research priorities.
Eligible applicant types
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Public and State controlled institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- Native American tribal governments (Federally recognized)
- For profit organizations other than small businesses
- City or township governments
- Public housing authorities/Indian housing authorities
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Small businesses
- Special district governments
- County governments
- Independent school districts
- Private institutions of higher education
Full description — from the agency
Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.
Topics: cancer clinical trial · early phase trial design · cancer diagnostics · cancer therapeutics · NIH R01 grant · investigator-initiated research
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.