Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
Last verified by NonDilute: 2026-04-29. Official notice and agency instructions control.
If you've built or are building generalizable computational tools or statistical methods for genomic analysis, the NIH will fund the R&D to harden and scale them across the biomedical research community.
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What this is
This R01-equivalent grant from the National Institute of General Medical Sciences and National Human Genome Research Institute targets fundamental genomics research in computational methods, statistical approaches, and bioinformatics tooling. The work should be methodologically innovative, generalizable across biological systems and diseases, and explicitly address scalability to large genomic datasets. Clinical trials are not permitted, and the focus is on enabling basic and clinical genomic science through software and analytical advances rather than hypothesis-driven disease research.
Who can apply
Wide eligibility including small businesses, nonprofits (with or without 501(c)(3) status), universities, tribal governments, and state/local entities. Solo individuals and for-profit companies are eligible. No geographic restrictions. Clinical trial-focused work is excluded.
Eligible applicant types
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- Native American tribal governments (Federally recognized)
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- Independent school districts
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- City or township governments
- County governments
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Special district governments
Full description — from the agency
The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All applications should address how the methods would scale to address increasingly larger data sets.
Topics: computational genomics · bioinformatics software · genomic data analysis · statistical methods genomics · scalable genomics tools · genome analysis pipeline
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.