Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If you've built a remote or mHealth platform for complementary health interventions and have preliminary trial data, NIH will fund your fully powered clinical trial—but you need rigorous methodology and proof of feasibility first.
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What this is
The National Center for Complementary and Integrative Health (NCCIH) is funding research-led clinical trials of remote and mHealth-delivered complementary health interventions in priority research areas. Applicants must design fully remote trials with no in-person contact, provide preliminary data on feasibility and safety, and demonstrate clinical promise. This is suitable for researchers and organizations with clinical trial experience, mHealth/remote delivery infrastructure, and access to patient populations for high-priority integrative health topics.
Who can apply
Broad eligibility including universities, nonprofits (501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations, government agencies, tribal organizations, and K-12 institutions. No explicit geographic restriction; U.S. federal funding typically requires U.S.-based organizations.
Eligible applicant types
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- For profit organizations other than small businesses
- Small businesses
- Private institutions of higher education
- Public housing authorities/Indian housing authorities
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- City or township governments
- County governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Special district governments
- Native American tribal organizations (other than Federally recognized tribal governments)
Full description — from the agency
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated fully remotely delivered and conducted clinical trials to assess the efficacy or effectiveness of complementary and integrative health interventions in NCCIH- designated areas of high research priority. Applications submitted under this NOFO are expected to propose a remotely delivered and conducted fully powered clinical trial with no in-person contact between research staff and study participants and may utilize mHealth tools or technologies. Applicants must provide justification for the remotely delivered approach and provide preliminary data on the feasibility and safety of the approach, along with evidence that the intervention has promise of clinical benefit. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.
Topics: remote clinical trials · mHealth interventions · complementary health · integrative medicine · digital health delivery
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.