Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If you have preliminary data on a mind-body intervention and need seed funding to prove recruitment, retention, and protocol feasibility before a larger NIH trial, this R34 is your pre-competitive tool.
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What this is
NCCIH is seeking feasibility clinical trial applications that test complementary and integrative health approaches combining physical and/or psychological interventions. The R34 mechanism funds small-scale trials designed to answer critical questions—recruitment feasibility, intervention acceptability, protocol refinement, retention procedures—that are scientifically necessary before launching a full-scale efficacy or effectiveness trial. Applicants must clearly articulate their planned future large trial and explain how the proposed feasibility work will fill knowledge gaps essential to its success. This is not a mechanism for full efficacy trials; it is for de-risking the design of future large trials in mind-body medicine.
Who can apply
Extremely broad eligibility: nonprofits (501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations, universities, government entities, tribal organizations, and many others can apply. There is no geographic restriction. However, applicants must have or partner with researchers capable of conducting clinical trials and must demonstrate scientific merit aligned with NCCIH's priority research topics.
Eligible applicant types
- For profit organizations other than small businesses
- Native American tribal governments (Federally recognized)
- State governments
- Independent school districts
- City or township governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Special district governments
- County governments
- Public and State controlled institutions of higher education
- Public housing authorities/Indian housing authorities
- Small businesses
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- Private institutions of higher education
Full description — from the agency
The goal of this notice of funding opportunity (NOFO) is to support feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) for conditions that have been identified by NCCIH as high-priority research topics. This funding opportunity is intended to support feasibility clinical trials that provide new information that are scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent competitive full-scale clinical trial. Under this R34, the data collected should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial, including, but not limited to the following: examining feasibility and acceptability of interventions lacking published data; tailoring or adapting the content or structure of an intervention to a specific population, modality, or setting; refining the intervention to determine the most appropriate frequency or duration; determining feasibility of recruitment, retention, and data collection procedures; refining and assessing the feasibility of protocolized multi-component interventions; or examining acceptability and adherence of control conditions. The subsequent full-scale clinical trial should have the potential to make a significant impact on public health. Prior to submitting to this NOFO, applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact person for the science area of the planned application.
Topics: mind-body interventions · feasibility clinical trial · complementary and integrative health · NCCIH research · clinical trial design · R34 grant
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.