New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)
Last verified by NonDilute: 2026-04-29. Official notice and agency instructions control.
If you've invented or adapted a method to reliably measure brain changes over years or decades, NIH will fund you to validate and scale it for longitudinal studies.
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What this is
This R01 grant funds multidisciplinary teams working on novel or improved measurement technologies and approaches for studying brain activity and structure longitudinally—across months, years, or decades. Applicants can study healthy participants, clinical populations with cognitive/motor/affective disorders, or animal models. The emphasis is on technological innovation that enables reliable repeated measurements over extended timescales to predict later-life health outcomes. Both human clinical trials and basic neuroscience research are eligible.
Who can apply
Extremely broad: universities, nonprofits (with or without 501(c)(3) status), small businesses, for-profit companies, state/local governments, tribal governments, and independent school districts all qualify. Solo researchers should partner with an eligible institutional sponsor; there is no explicit individual-researcher category.
Eligible applicant types
- County governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- City or township governments
- Small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Public and State controlled institutions of higher education
- State governments
- Private institutions of higher education
- Special district governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- Native American tribal governments (Federally recognized)
- For profit organizations other than small businesses
- Independent school districts
Full description — from the agency
The purpose of this funding opportunity is to encourage multidisciplinary investigators to develop new approaches or apply existing approaches in novel ways to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment. The overarching goal is to extend our understanding of brain development and aging, including studies of the neurodevelopmental origins of later health and disease. Research can include healthy human participants of any age, specific clinical groups such as those with cognitive, motor, or affective regulation challenges, and/or animal research on these domains of function. The studies can focus on longitudinal neuroanatomical or functional changes at any level, including genetics/genomics, single cells, connectomics, neural population activity patterns, and others. This funding opportunity is intended to encourage technological and conceptual innovation to improve repeated measures across longer epochs of the lifespan, to better predict outcomes at later ages.
Topics: longitudinal neuroimaging · brain measurement · neurodevelopment · aging research · connectomics · neurogenomics · repeated measures
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.