Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
Fund your innovative clinical trial using NIH's built clinical research infrastructure if you're studying women, children, pregnant/lactating populations, or persons with disabilities.
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What this is
This is a two-phase clinical research opportunity from the National Institute of Child Health and Human Development (NICHD) designed to support investigator-initiated, multisite studies leveraging existing NIH clinical research networks. The UG3 phase funds planning and milestone achievement; successful UG3 projects transition to the UH3 phase for full enrollment and implementation. Applicants must partner with an NICHD-supported Network Data Coordinating Center. This is ideal for researchers with innovative hypotheses targeting women's health, pediatrics, maternal/lactation research, or disability studies who need infrastructure support to execute larger clinical trials.
Who can apply
Extremely broad eligibility: nonprofits (501(c)(3) and non-tax-exempt), universities, small businesses, for-profit firms, tribal governments, government agencies, and independent schools. Solo researchers must apply through an eligible institutional sponsor. No geographic restrictions. Geographic preference for projects involving NICHD network sites.
Eligible applicant types
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- County governments
- City or township governments
- Special district governments
- State governments
- Independent school districts
- Native American tribal governments (Federally recognized)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- Small businesses
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Public and State controlled institutions of higher education
Full description — from the agency
The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.
Topics: clinical trials · NICHD networks · women's health · pediatric research · maternal health · disability studies · multisite studies · investigator-initiated research
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.