NIH Research Project Grant (Parent R01 Clinical Trial Required)
Last verified by NonDilute: 2026-04-29. Official notice and agency instructions control.
If you have a clinical trial-ready biomedical research project, NIH R01 is the gold-standard federal funding mechanism across dozens of health-related scientific areas.
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What this is
This is a foundational NIH grant mechanism for established researchers proposing clinical trial-based studies. The funding is extremely broad—covering 25 different CFDA codes across multiple NIH institutes—but carries a hard requirement: your project must include at least one clinical trial. Eligible applicants range from small businesses to universities, nonprofits, and government entities. This is a traditional NIH grant with competitive peer review and typical application complexity.
Who can apply
Remarkably broad: for-profit companies (including small businesses), universities (public and private), nonprofits with or without 501(c)(3) status, Native American tribal governments, state/county/city governments, and other entities. Applicants must propose at least one clinical trial aligned with the scientific mission of at least one NIH Institute or Center.
Eligible applicant types
- For profit organizations other than small businesses
- Private institutions of higher education
- City or township governments
- Public and State controlled institutions of higher education
- Special district governments
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- State governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal governments (Federally recognized)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Small businesses
- Public housing authorities/Indian housing authorities
Full description — from the agency
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
Topics: nih r01 grant · clinical trial funding · biomedical research · health research grant · nih institutes and centers
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.