Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If you're designing or testing a health intervention for Native American or Alaska Native populations, NIH will fund development through scale-up with flexible timelines and implementation support.
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What this is
This NIH program funds research aimed at reducing health disparities in Native American and Alaska Native communities through culturally informed interventions. Eligible research spans foundational etiologic work, development and testing of health promotion and disease prevention interventions, culturally tailored treatment approaches, and implementation science to scale proven interventions. Projects should leverage community knowledge and resilience, be designed for sustainability and adaptation, and address the unique sociopolitical, historical, and environmental stressors affecting these populations.
Who can apply
Extremely broad eligibility: universities, tribal governments, nonprofits (501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations, state/local governments, and Native American tribal organizations all qualify. No geographic restrictions beyond focus on Native American/Alaska Native populations.
Eligible applicant types
- Private institutions of higher education
- Special district governments
- State governments
- City or township governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- County governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Public and State controlled institutions of higher education
- Small businesses
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments (Federally recognized)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
Full description — from the agency
The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).
Topics: native american health research · health disparities intervention · culturally informed treatment · implementation science health · indigenous health equity · disease prevention alaska natives · health promotion intervention development
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.