Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV
Last verified by NonDilute: 2026-06-08. Official notice and agency instructions control.
If your lab studies CNS disease mechanisms or HIV pathogenesis, this NIH program funds rigorous mechanistic research to identify druggable targets in HIV-related neurological disease.
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What this is
This is a mechanistic research program administered by the NIH's National Institute of Neurological Disorders and Stroke (CFDA 93.242) focused on understanding why and how HIV damages the central nervous system, and identifying specific biological targets that can be therapeutically addressed. Researchers are expected to investigate the pathways underlying HIV-associated neurocognitive disorders and other CNS complications, with emphasis on defining treatable traits that could improve patient outcomes. This is foundational science and translational research rather than clinical trials, making it suitable for academic institutions, research hospitals, and established biotech firms with strong neuroscience capabilities.
Who can apply
Eligible applicants typically include universities, medical schools, research hospitals, and non-profit research institutions; specific eligibility for small businesses or solo researchers is not detailed in this announcement and should be confirmed with NIH. Applicants must have institutional capacity to conduct federally-funded research including regulatory compliance and human/animal subject oversight.
Topics: hiv neuroscience · cns therapeutic targets · neuroinfection research · treatable traits · neuroaids mechanisms · hiv neurocognitive disorders
Public-source funding discovery only. This summary is generated from public agency data and may be incomplete or stale. NonDilute is not affiliated with, endorsed by, or acting on behalf of any government agency. Official notices and agency instructions control. NonDilute does not determine eligibility, provide grant-writing advice, or guarantee funding.